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Estimado (a) Dr. (a.),

La presencia de obesidad se encuentra asociada a daño en múltiples órganos y sistemas, siendo el hígado uno en los que tiene mayor impacto.¹ La enfermedad del hígado graso asociada a la disfunción metabólica (MAFLD) denota el mórbido paralelismo del MAFLD con la obesidad y el síndrome metabólico.²

En la siguiente infografía, el Dr. Genaro Vázquez Elizondo nos ilustra sobre “El impacto del MAFLD en la salud”, material de gran actualidad pues se ha convertido en la causa más frecuente de hepatopatía crónica en el mundo, ya sea por las consecuencias del daño directo al hígado o como parte de una constelación metabólica. (²,³)

Su reconocimiento y tratamiento temprano ayudarán a mejorar y prevenir enfermedades con impactos negativos en nuestros pacientes.

 

Referencias:

  1. Lin X, Li H. Obesity: Epidemiology, Pathophysiology, and Therapeutics. Front Endocrinol [Internet]. 2021 Sep [cited 2022 Oct 25]; 12:706978. Available from: https://www.frontiersin.org/articles/10.3389/fendo.2021.706978/full
  2. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther [Internet].2011 Aug [cited 2022 Feb 22];34(3):274-85. Available from: https://pubmed.ncbi.nlm.nih.gov/21623852/.
  3. Marengo A, Rosso C, Bugianesi E. Liver Cancer: Connections with Obesity, Fatty Liver, and Cirrhosis. Annu Rev Med [Internet]. 2016 Oct [cited 2022 Feb 22];67:103-17. Available from: https://pubmed.ncbi.nlm.nih.gov/26473416/.
  4. Tilg H, Effenberger M. From NAFLD to MAFLD: when pathophysiology succeeds. Nat Rev Gastroenterol Hepatol. 2020;17(7):387-8.
  5. Sanyal A J, Banas C, Sargeant C, Luketic VA, Sterling RK, Stravitz RT, et al. Similarities and differences in outcomes of cirrhosis due to nonalcoholic steatohepatitis and hepatitis C. Hepatology [Internet]. 2006 Apr [cited 2022 Feb 22];43(4):682-9. Available from: https://pubmed.ncbi.nlm.nih.gov/16502396/.
  6. Lazo M, Clark JM. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis [Internet]. 2008 Nov [cited 2022 Feb 22];28(4):339-50. Available from: https://pubmed.ncbi.nlm.nih.gov/18956290/.
  7. Lopez-Velazquez JA, Silva-Vidal KV, Ponciano-Rodriguez G, Chavez-Tapia NC, Arrese M, Uribe M, et al. The prevalence of nonalcoholic fatty liver disease in the Americas. Ann Hepatol [Internet]. 2014 Mar [cited 2022 Feb 22];13(2):166-78. Available from: https://www.imbiomed.com.mx/articulo.php?id=99797.
  8. Li AA, Ahmed A, Kim D. Extrahepatic Manifestations of Nonalcoholic Fatty Liver Disease. Gut Liver [Internet]. 2020 Mar [cited 2022 Oct 25]; 14 (2): 168-178. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7096231/
  9. Huang DQ, El-Serag HB, Loomba R. Global epidemiology of NAFLD-related HCC: trends, predictions, risk factors and prevention. Nat Rev Gastroenterol Hepatol [Internet]. 2021 Apr [cited 2022 Feb 22];18(4):223-38. Available from: https://pubmed.ncbi.nlm.nih.gov/33349658/.
  10. Kanwal F, Singal AG. Surveillance for Hepatocellular Carcinoma: Current Best Practice and Future Direction. Gastroenterology [Internet]. 2019 Jul [cited 2022 Feb 23];157(1):54-64. Available from: https://pubmed.ncbi.nlm.nih.gov/30986389/.
  11. Yoo JJ, Cho E J, Chung GE, Chang Y, Cho Y, Park SH, et al. Nonalcoholic Fatty Liver Disease Is a Precursor of New-Onset Metabolic Syndrome in Metabolically Healthy Young Adults. J Clin Med [Internet]. 2022 Feb [cited 2022 Feb 23];11(4). Available from: https://europepmc.org/article/MED/35207209.
  12. Allen AM, Therneau TM, Larson JJ, Coward A, Somers VK, Kamath PS. Nonalcoholic fatty liver disease incidence and impact on metabolic burden and death: A 20 year-community study. Hepatology [Internet]. 2018 May [cited 2022 Feb 23];67(5):1726-36. Available from: https://pubmed.ncbi.nlm.nih.gov/28941364/.
  13. Bril F, Cusi K. Nonalcoholic Fatty Liver Disease: The New Complication of Type 2 Diabetes Mellitus. Endocrinol Metab Clin North Am [Internet]. 2016 Dec [cited 2022 Feb 23];45(4):765-81. Available from: https://pubmed.ncbi.nlm.nih.gov/27823604/.
  14. Targher G, Bertolini L, Poli F, Rodella S, Scala L, Tessari R, et al. Nonalcoholic fatty liver disease and risk of future cardiovascular events among type 2 diabetic patients. Diabetes [Internet]. 2005 Dec [cited 2022 Feb 23];54(12):3541-6. Available from: https://www.semanticscholar.org/paper/Nonalcoholic-fatty-liver-disease-and-risk-of-future-Targher-Bertolini/d54c1d493b06ca8bcce2f718a9fc2af1835687f4.

 

Para descargar la infografía en PDF haga click aquí.

Material exclusivo para profesionales de la salud.

La información aquí presentada es opinión del ponente.

Material desarrollado con fines de educación médica continua.

Código interno de aprobación: MX22SX00060.

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